Immunotherapy prior to surgery is effective in CRC patients

Patients with colon cancer but without distant metastases can benefit from a short course of immunotherapy while waiting for their surgery, as it can cause tumours to shrink substantially or clear up in a very short time, according to the finding of a NICHE study by the Netherlands Cancer Institute, an innovatory phase II clinical trial.

Modified metabolite could improve colon cancer treatment

Using a modified natural substance along with current approaches could improve colon cancer treatment, according to researchers at the University of California, Irvine biologists. The discovery comes from their research into the role of an amino acid in tumour development and a potential method for reversing the process. The paper, ‘{{α-Ketoglutarate attenuates Wnt signaling and drives differentiation in colorectal cancer}}’, was published in Nature Cancer.

Blocked fibroblast signalling to intestinal stem cells reduces tumour growth

Scientists at Yale and collaborators in Greece have identified a tightly sequestered group of stem cells within the intestine as suspects in the development of colon cancer and report that unprepossessing neighbours of stem cells actually harbour a molecular villain that can jump-start cancers of the colon.

Sequencing of the intestinal microbiota for colorectal cancer

The intestinal microbiota, composed of the microorganisms that live in our intestines, can give us information about our health, since its composition may depend on factors such as the diet, lifestyle or our pathologies. Moreover, knowing what specific bacteria are in our intestines could help to predict diseases like colon cancer. New advances in genome sequencing methods, and bioinformatics tools that allow us to analyze the data, have helped us to identify thousands of new microorganisms present in our intestines through the analysis of their genome.

COVID-19: Critical care team develops blueprint for essential surgery

As patients with Coronavirus Disease 2019 (COVID-19) flood hospitals, the health care system must not only determine how to redeploy limited resources and staff to care for them but must also make well-calculated decisions to provide other types of critical care. For surgeons, this type of critical care involves performing an emergency operation to treat a ruptured appendix or perforated colon, to both virus-exposed and non-exposed patients, while keeping both hospital personnel and non-exposed patients safe.

ACPGBI issues COVID-19 guidance for colorectal surgeons and trainees

The Association of Coloproctology of Great Britain and Ireland has issued COVID-19 guidance for colorectal surgeons and trainees to provide a framework in which to prepare and act, and should be used in conjunction with the frequently updated national government recommendations available from Public Health England, Health Protection Scotland, Public Health Wales and Public Health Agency Northern Ireland.