Looking forward to Dublin 2019: An interview with ESCP President, Per Nilsson

In a series of interviews, we will be previewing this year’s ACPGBI annual meeting in Dublin, 1-3 July. We talked to Dr Per Nilsson, Consultant Colorectal Surgeon and Senior Lecturer at Karolinska University Hospital, Sweden and current President of the European Society of Coloproctology, who discussed the benefits and current evidence for ‘Watch and wait’ and surgery for regrowth after neoadjuvant radiotherapy for rectal cancer.

Fitness may affect risk of colorectal cancer and survival likelihood after diagnosis

Adults who were the most fit had the lowest risk of developing colorectal and lung cancer, and among individuals who developed lung or colorectal cancer, those who had high fitness levels before their cancer diagnosis were less likely to die compared with those who had low fitness levels. The findings, ‘Cardiorespiratory Fitness and Incident Lung and Colon Cancer in Men and Women: Results from the Henry Ford Exercise Testing (FIT) Cancer Cohort’, were published in Cancer, a peer-reviewed journal of the American Cancer Society.

Screening for colorectal cancer at 45 would avert 11,100 deaths over five years

Starting routine colorectal cancer screening at age 45 rather than 50 would decrease US cancer deaths by as much as 11,100 over five years, according to a new study led by researchers at the Stanford University School of Medicine. The move would also decrease the number of cancer cases nationwide by up to 29,400 over that time period. However, screening a greater number of older and high-risk adults would avert nearly three times as many diagnoses and deaths at a lower cost, the study found.

Integrated stratifying method for improved prognosis for colorectal cancer patients

A method that integrates tumour buds, lymphocytic infiltration, and their spatial relationship could better stratify patients with stage 2 colorectal cancer (CRC) at high risk for disease-specific death compared with traditional methods of clinical staging, according to results ‘Automated Analysis of Lymphocytic Infiltration, Tumor Budding, and Their Spatial Relationship Improves Prognostic Accuracy in Colorectal Cancer’,  published in Cancer Immunology Research, a journal of the American Association for Cancer Research.

Potential new compound therapy for inflammatory bowel disease

Researchers at Washington University School of Medicine in St Louis have found a compound that may treat inflammatory bowel disease (IBD) without directly targeting inflammation. The compound tamps down the activity of a gene linked to blood clotting. They discovered that the gene was turned on at sites of intestinal inflammation and damage, and blocking its activity reduces IBD symptoms in mice. The research was featured in the paper, ‘PAI-1 augments mucosal damage in colitis,’ published in Science Translational Medicine.

Common oral bacteria make colon cancer more deadly

Researchers at the Columbia University College of Dental Medicine have determined how F. nucleatum - a common oral bacteria often implicated in tooth decay—accelerates the growth of colon cancer. The study, ‘Fusobacterium nucleatum promotes colorectal cancer by inducing Wnt/ß-catenin modulator Annexin A1’,  was published online in the journal EMBO Reports.

West Virginia University Cancer Institute researchers pursue blood test for colorectal cancer

Researchers at the West Virginia University Cancer Institute are evaluating a first-of-its-kind blood test for detecting colorectal cancer. Their findings may help propel the test toward inclusion in the US Preventive Services Task Force's recommendations for colorectal cancer screening.