Screening for colorectal cancer at 45 would avert 11,100 deaths over five years

Starting routine colorectal cancer screening at age 45 rather than 50 would decrease US cancer deaths by as much as 11,100 over five years, according to a new study led by researchers at the Stanford University School of Medicine. The move would also decrease the number of cancer cases nationwide by up to 29,400 over that time period. However, screening a greater number of older and high-risk adults would avert nearly three times as many diagnoses and deaths at a lower cost, the study found.

Integrated stratifying method for improved prognosis for colorectal cancer patients

A method that integrates tumour buds, lymphocytic infiltration, and their spatial relationship could better stratify patients with stage 2 colorectal cancer (CRC) at high risk for disease-specific death compared with traditional methods of clinical staging, according to results ‘Automated Analysis of Lymphocytic Infiltration, Tumor Budding, and Their Spatial Relationship Improves Prognostic Accuracy in Colorectal Cancer’,  published in Cancer Immunology Research, a journal of the American Association for Cancer Research.

Potential new compound therapy for inflammatory bowel disease

Researchers at Washington University School of Medicine in St Louis have found a compound that may treat inflammatory bowel disease (IBD) without directly targeting inflammation. The compound tamps down the activity of a gene linked to blood clotting. They discovered that the gene was turned on at sites of intestinal inflammation and damage, and blocking its activity reduces IBD symptoms in mice. The research was featured in the paper, ‘PAI-1 augments mucosal damage in colitis,’ published in Science Translational Medicine.

Common oral bacteria make colon cancer more deadly

Researchers at the Columbia University College of Dental Medicine have determined how F. nucleatum - a common oral bacteria often implicated in tooth decay—accelerates the growth of colon cancer. The study, ‘Fusobacterium nucleatum promotes colorectal cancer by inducing Wnt/ß-catenin modulator Annexin A1’,  was published online in the journal EMBO Reports.

West Virginia University Cancer Institute researchers pursue blood test for colorectal cancer

Researchers at the West Virginia University Cancer Institute are evaluating a first-of-its-kind blood test for detecting colorectal cancer. Their findings may help propel the test toward inclusion in the US Preventive Services Task Force's recommendations for colorectal cancer screening.

Pentax Medical launches integrated endoscopy solutions platform

Pentax Medical has launched two dedicated electrosurgical and argon plasma coagulation (APC) platforms - the Endo arc and Endo Plus - to its therapeutic accessories range. The launch of these units strengthens Pentax Medical’s integrated endoscopy solutions offering, completing the pathway from screening to diagnostics and into therapeutics.

Researchers identify enzymes involved in colon cancer growth

University of Massachusetts Amherst food science researchers have pinpointed a set of enzymes involved in tumour growth that could be targeted to prevent or treat colon cancer. The study, ‘Targeted metabolomics identifies the cytochrome P450 monooxygenase eicosanoid pathway as a novel therapeutic target of colon tumorigenesis,’ was published in the journal Cancer Research.