microRNAs are predictors of Crohn's disease progression

A new study conducted in adult and paediatric patients with Crohn's disease, led by UNC School of Medicine researchers and published in the Journal of Clinical Investigation Insight, has found that a set of biomolecules known as microRNAs, specifically microRNA-31 (miR-31), can help predict which patients with Crohn's disease are at higher risk for the development of severe problems that may require surgical removal of the large intestine.

Bowel Cancer UK campaigns to end bowel cancer capacity crisis

Bowel Cancer UK has handed in an open letter to the to the UK government calling for a fully funded action plan to tackle NHS staff shortages in diagnostic services for bowel cancer – England’s second biggest cancer killer. The letter comes ahead of the Government spending review and calls on the Chancellor and Health Secretary to invest in more NHS staff to cope with the rising demand for bowel cancer tests.

Inflammatory proteins in the colon increase incrementally with weight

A new study shows that two inflammatory proteins in the colon increase in parallel with increasing weight in humans. An incremental rise in these pro-inflammatory proteins (called cytokines) was observed along the entire spectrum of subjects' weights, which extended from lean to obese individuals. In participants with obesity, there was evidence that two pre-cancerous cellular pathways known to be triggered by these cytokines were also activated.

ESCP studies to assess surgical techniques and post-operative outcomes for patients

European Society for Coloproctology (ESCP) has announced it is establishing additional cohort studies on robotic colorectal surgery, the management of acute severe Ulcerative Colitis and parastomal hernia repair in 2019. The ESCP has previously undertaken a major international audit of colorectal operations to understand which are most widely used techniques across the world, which appear to be associated with the best outcomes and where further research needs to be undertaken.

Single cell analysis and Inflammatory Bowel Disease treatments

A new study by the group of Professor Alison Simmons at the MRC Human Immunology Unit based in the MRC Weatherall Institute of Molecular Medicine, Oxford, UK, paves the way for better treatments for Inflammatory Bowel Disease (IBD) by providing the first detailed single cell resolution analysis of colon cells in health and disease.

The biological links between obesity and gastrointestinal cancers

There are many studies that have demonstrated a connection between obesity and a person's risk of developing colon and other gastrointestinal cancers, and scientists at the Huntsman Cancer Institute's National Cancer Institute-designated Comprehensive Cancer Cente are investigating approaches that can break this relationship.

Appendectomy for ulcerative colitis voted best research paper ESCP

The European Society of Coloproctology (ESCP) has announced the winner of its best abstract research paper as ‘Therapy refractory ulcerative colitis patients may benefit from appendectomy’ by Dr Merle Stellingwerf and colleagues at its 13th Annual Conference in Nice, France. Merle Stellingwerf was confirmed as the winner on the back of her presentation at the ‘Six Best Papers’ session at the event which is attended and voted on by specialists from across Europe.