Benign growths more heterogeneous than colorectal cancer tumours

Chromosomal catastrophes have been found to occur along the evolutionary timeline of colorectal cancer  development, according to new research led by Queen Mary University of London. The paper, 'The evolutionary landscape of colorectal tumorigenesis', published in Nature Ecology & Evolution, compared the genetics of benign and cancerous bowel tumours and revealed that the benign growths were more heterogeneous than the cancerous tumours.

Positive results for ABX464 as an oral treatment ulcerative colitis

Abivax has announced topline results from its Phase 2a clinical trial, ABX464-101, conducted in 32 patients for induction treatment of moderate-to-severe ulcerative colitis (UC), refractory to anti-TNF monoclonal antibodies or corticosteroids. In summary, the topline data indicate that ABX464 was safe, well-tolerated, and demonstrated statistically significant efficacy based on both clinical and endoscopic endpoints in this study.

Pre-emptive analgesia may cut post-op pain in anorectal surgery

Preemptive pain medication is safe and reduces pain in the early postoperative period for patients undergoing anorectal surgery (ARS), according to a study published in the journal of Diseases of the Colon & Rectum. The researchers found that patients in the active group had significantly less pain in the post-anaesthesia care unit and at eight hours postoperatively. Furthermore, significantly fewer participants in the active group used narcotics in the post-anaesthesia care unit and at eight hours postoperatively.