Researchers identify novel genetic factors for colorectal cancer risk

A large-scale study conducted among East Asians and led by Vanderbilt University researchers has identified multiple, previously unknown genetic risk factors for colorectal cancer. The research paper, ‘Large-scale Genome-wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer,’ published in Gastroenterology, is the second largest discovery of novel genetic risk variants for colorectal cancer in a single study published to date.

Researchers ID new biomarker for colorectal cancers

Johns Hopkins researchers have identified a protein involved in cell proliferation and the development of new blood vessels that could serve as a marker for the early detection of colorectal cancers. The paper, ‘Lactosylceramide synthase β-1,4-GalT-V: A novel target for the diagnosis and therapy of human colorectal cancer,’ was published in the journal, Biochemical and Biophysical Research Communications.

New approach to bowel cancer analysis could lead to better prognosis for patients

Researchers from Queen’s University have demonstrated how a precise integration of the results of both pathological and molecular analysis of tumour and normal tissue from the bowel can ensure a correct interpretation of the data, providing a more accurate result that can underpin better treatment options for bowel cancer patients. The paper, ‘Epithelial-to-mesenchymal transition signature assessment in colorectal cancer quantifies tumour stromal content rather than true transition,’ in the journal The Journal of Pathology.

Ten-year follow-up after negative colonoscopies linked to lower colorectal cancer risk

Ten years after a negative colonoscopy, Kaiser Permanente members had 46 percent lower risk of being diagnosed with and were 88 percent less likely to die from colorectal cancer compared with those who did not undergo colorectal cancer screening, according to a study, ‘Long-term Risk of Colorectal Cancer and Related Deaths After a Colonoscopy With Normal Findings’, published in JAMA Internal Medicine.

Researchers develop personalised tool for inherited colorectal cancer syndrome

An international team of researchers led by Huntsman Cancer Institute (HCI) at the University of Utah (U of U) has developed, calibrated, and validated a novel tool for identifying the genetic changes in Lynch syndrome genes that are likely to be responsible for causing symptoms of the disease. The paper, ‘A functional assay–based procedure to classify mismatch repair gene variants in Lynch syndrome,’ was published in Genetics in Medicine

Exercise following weight loss may reduce colorectal cancer risk

New research suggests that exercise is a key factor in reducing colorectal cancer risk after weight loss. According to the study, physical activity causes beneficial changes in the bone marrow. The study, ‘Effects of obesity and exercise on colon cancer induction and hematopoiesis in mice,’ was published in the journal American Journal of Physiology-Endocrinology and Metabolism.

Loss of two genes drives a deadly form of colorectal cancer, revealing potential treatment

Scientists from Sanford Burnham Prebys Medical Discovery Institute (SBP), in collaboration with clinicians from Scripps Clinic, have identified that the loss of two genes drives the formation of serrated colorectal cancer, yielding potential biomarkers. The research has also identified a combination treatment that has treated the cancer in mice. The paper, ‘Simultaneous Loss of Both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance,’ was published in the journal Immunity.