Machine learning algorithm identifies precancerous colon polyps

A machine learning algorithm helps accurately differentiate benign and premalignant colorectal polyps on CT colonography scans, according to researchers from the University Hospital, Ludwig Maximilian University of Munich, Munich Germany. The findings were reported in the paper, ‘Machine Learning–based Differentiation of Benign and Premalignant Colorectal Polyps Detected with CT Colonography in an Asymptomatic Screening Population: A Proof-of-Concept Study’, published in the journal Radiology.

Nanotherapy is a potential therapy for Crohn's disease in children

Scientists from the Stanley Manne Children's Research Institute at Ann & Robert H Lurie Children's Hospital of Chicago have reported that a nanotherapy reduces intestinal inflammation and shrinks lesions in a rodent model of severe Crohn's disease. This approach could become an alternative to biologic antibody therapies that carry many side effects, including increased risk of certain cancers and might also prevent the need for surgery in the future.

Genotoxin colibactin induces genetic changes leading to development of CRC cells

Researchers from the Max Planck Institute for Infection Biology in Berlin have reported that the genotoxin colibactin induces genetic changes that are characteristic of colorectal cancer cells and cause a transformed phenotype after only a few hours of infection. The findings were featured in the paper, ‘Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells’, published in Nature Communications.