Immunotherapy prior to surgery is effective in CRC patients

Patients with colon cancer but without distant metastases can benefit from a short course of immunotherapy while waiting for their surgery, as it can cause tumours to shrink substantially or clear up in a very short time, according to the finding of a NICHE study by the Netherlands Cancer Institute, an innovatory phase II clinical trial.

Modified metabolite could improve colon cancer treatment

Using a modified natural substance along with current approaches could improve colon cancer treatment, according to researchers at the University of California, Irvine biologists. The discovery comes from their research into the role of an amino acid in tumour development and a potential method for reversing the process. The paper, ‘{{α-Ketoglutarate attenuates Wnt signaling and drives differentiation in colorectal cancer}}’, was published in Nature Cancer.

Blocked fibroblast signalling to intestinal stem cells reduces tumour growth

Scientists at Yale and collaborators in Greece have identified a tightly sequestered group of stem cells within the intestine as suspects in the development of colon cancer and report that unprepossessing neighbours of stem cells actually harbour a molecular villain that can jump-start cancers of the colon.

Sequencing of the intestinal microbiota for colorectal cancer

The intestinal microbiota, composed of the microorganisms that live in our intestines, can give us information about our health, since its composition may depend on factors such as the diet, lifestyle or our pathologies. Moreover, knowing what specific bacteria are in our intestines could help to predict diseases like colon cancer. New advances in genome sequencing methods, and bioinformatics tools that allow us to analyze the data, have helped us to identify thousands of new microorganisms present in our intestines through the analysis of their genome.