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Potent parasite protein may lead to new treatment for inflammatory bowel conditions

Mon, 11/27/2017 - 10:01
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Treatment approaches are being explored such as T cell therapy - taking a patient's T cells and converting them to Tregs and giving them back to the patient

A single protein from a worm parasite may offer new therapeutic options for treating inflammatory bowel diseases like Crohn's Disease or ulcerative colitis, that avoid the potentially serious side effects of current immunosuppressant medications. The study, 'A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells,' is published in Nature Communications,’ published in Nature Communications, demonstrates the discovery of a distinct new worm protein which mimics a cytokine found in humans, known as transforming growth factor-beta (TGF-β). The newly-discovered protein switches off inflammation by inducing ‘regulatory T cells’, the body's own means of dampening excessive reactivity.

The so-called ‘Hygiene Hypothesis’ suggests that some bugs and parasites may protect you from an overly-reactive immune system, which can cause allergy and other disorders. Harnessing this route of immune regulation is potentially a much safer option than our currently-available medications can offer.

"Discovering a new protein that can potently induce regulatory T cells (Tregs) from human cells is unexpected and very exciting in terms of finding a new potential biologic for inflammation conditions,” said first author of the study Dr Danielle Smyth, Research Associate in Parasitology at the Institute of Infection, Immunity and Inflammation. "We hope to explore this option and see whether the Tregs our parasite molecule induce offers a regulatory advantage over current treatments."

Inflammatory bowel diseases are made up of many variations, and each patient requires to be treated in an individual manner. As such, treatment approaches are being explored such as T cell therapy (taking a patient's T cells and converting them to Tregs and giving them back to the patient).

Rick Maizels, Professor of Parasitology at the Institute, said: "The next horizon for these exciting findings will be to test whether the new protein can be used to treat inflammatory diseases, reaping the benefits of the 'hygiene hypothesis' and dispensing with the parasites themselves."

To access this paper, please click here