An analysis of electronic medical records indicates that patients who previously had a false-positive breast or prostate cancer screening test are more likely to obtain future recommended cancer screenings. Published Cancer, a peer-reviewed journal of the American Cancer Society, the study, ‘Implications of false‐positive results for future cancer screenings’ suggests that false-positives may be reminders to screen for cancer. For example, the study reported that women with a false-positive mammogram were at least 43% more likely to obtain future breast cancer screenings, and the same women were at least 25% more likely to obtain future colorectal cancer screenings. Additional studies are needed to explore whether false-positives have a detrimental effect on quality of life or increase anxiety about cancer.
False-positive cancer screening test results - when results that are suggestive of cancer ultimately turn out to be wrong - are common. Over ten years, about 50 to 60 in 100 women who get annual mammograms, 23 in 100 people who get regular stool tests, and ten to 12 in 100 men who get regular prostate cancer testing will have false-positive results. Such results may affect individuals' willingness to continue screening for cancer in the future, causing them to be either more diligent or more reluctant about getting screened.
To investigate, DrGlen Taksler of the Cleveland Clinic, and his colleagues obtained ten years of electronic medical records data to analyse the association between prior receipt of a false-positive cancer screening test result and future participation in routine cancer screenings. The records pertained to 92,405 individuals aged 50 to 75 years.
Interestingly, the results were stronger for individuals with a greater number of false-positive results. However, women with previous false-positive faecal occult blood testing (a type of colorectal cancer screening) were less likely to be up-to-date with breast cancer screening.
"We don't know why the observed pattern occurred," said Dr Taksler. "False-positives are a limitation of the technology that we use to check for cancer. Hopefully, over time, the technology will improve so that patients don't have to deal with as many false-positives."
He noted that other researchers have reported results that conflict with this study's findings, indicating the need for more research.