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Study shows annual non-invasive stool test effective for colon cancer screening

Tue, 02/26/2019 - 16:17
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A study by Indiana University School of Medicine and the Regenstrief Institute provides the strongest evidence to date to support recommendations that average risk patients can safely opt for an annual, easy-to-use home stool test instead of a screening colonoscopy, according to the outcomes from a study published in the Annals of Internal Medicine.

The researchers reviewed and analysed the findings of 31 studies with a total of 120,255 participants. Each individual had a FIT (short for faecal immunochemical test), which identifies hidden blood in stool. FIT results were compared to the finding of a subsequent screening colonoscopy and were found to have high detection rates for colorectal cancer.

Colonoscopy is considered to be the gold standard in the United States for colon cancer screening, and it is often performed in average-risk, asymptomatic adults 50 and older. But, in other countries, such as the United Kingdom, Canada, and Italy, colonoscopy is typically performed for average risk individuals with no symptoms only if FIT results are positive.

The US Preventive Services Task Force currently recommends screening for colorectal cancer using faecal occult blood testing - the category that includes FIT - sigmoidoscopy, colonoscopy, and other tests from age 50 to age 75, without preferentially recommending one particular screening test.

"Our analysis finds that FIT is a good 'pre-screening' test for average risk, asymptomatic adults, saving them hassle and the US healthcare system costs," said Dr Thomas Imperiale, the lead author, a gastroenterologist with IU School of Medicine and a research scientist with the Regenstrief Institute. "If annual FIT results remain negative, FIT buys you time until colonoscopy may be required, and it could be the case that a colonoscopy for screening may never be necessary or required."

Imperiale added that research indicates a similar approach could be safely deployed in the US and elsewhere, but only if there is a system to ensure annual testing.

"We need a system that is population-based rather than the current opportunistic one - with better laboratory-physician coordination, dedicated follow-up, and assurance that colonoscopy is performed if FIT results are positive," he said. "The power of FIT is in its repeat application and in many cases, repeatedly negative results."

Of the more than 4,000 English-language studies on FIT that Imperiale and Rachel Gruber, a Regenstrief Institute research coordinator, reviewed, only the 31 studies that were analysed included both FIT and colonoscopy results for each study participant. Approximately a third of the participants with positive FIT results in these 31 studies were found to have an advanced precancerous polyp or actual colon cancer.