An intelligent recognition method has been developed and firstly applied to achieve automatic lymph node (LN) detection and segmentation (auto-LNDS) of rectal cancer patients before surgery. This development was achieved by Gao Xin's research team from the Suzhou Institute of Biomedical Engineering and Technology of the Chinese Academy of Sciences (SIBET, CAS), in collaboration with MENG Xiaochun from Sixth Affiliated Hospital of Sun Yat Sen University, and other three 3A hospitals spread across different regions in China. The research, ‘Deep learning–based fully automated detection and segmentation of lymph nodes on multiparametric-MRI for rectal cancer: a multicenter study’, funded by the National Natural Science Foundation of China, was published in EBioMedicine.
In total, 373 patients with rectal cancer were enrolled in this study. The annotations of three senior experts were used as the ground truths for model training. Fused T2-weighted images (T2WI) and diffusion-weighted images (DWI) provided input for the deep learning framework of Mask R-CNN through transfer learning to generate the auto-LNDS model.
The results show that the model has an excellent performance in detecting different scales LNs compared with other reported algorithms (Figure 1). The size of the detected LNs is smaller (the short diameter is as small as 3mm), and the accuracy is higher, which is better than the reported algorithms and junior radiologists. In addition, it takes only 1.37 seconds to detect and segment all the LNs of a patient, which is 131 times faster than the doctor's detection speed.
The authors believe this model could help to minimise differences in LNs detection between radiologists, increase the efficiency of the clinical workflow and also has the potential to assist physicians in determining the nodal stage. In addition, this method can be extended to the preoperative evaluation of N staging of tumours in various parts of the body based on multimodal images (PET, CT, MRI, etc.), which has a high clinical significance and play an important enlightenment role for automatic identification of LNs in the chest, abdomen and even the whole body.
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