Abnormalities in laminin expression associated with Hirschsprung disease

Researchers from Le Bonheur Children's Hospital and the University of Tennessee Health Science Center who are trying to determine the mechanisms underlying abnormal development of the enteric nervous system in Hirschsprung disease, have reported delineating interactions between migrating neural crest cells and the extracellular matrix in a model of Hirschsprung disease using a variety of in vitro and in vivo approaches.

Bone marrow transplant cures rare form of inflammatory bowel disease

A rare genetic condition which causes inflammatory bowel disease (IBD) can be successfully treated by bone marrow transplant, according to University of Manchester and Manchester University NHS Foundation Trust researchers. The disease, called G6PC3 deficiency, affects around one in a million people and causes inflammation of the bowel, as well as lung infections.

Semi-autonomous robotic colonoscopy aims to make the procedure easier

An international team of scientists, led by the University of Leeds, have made a breakthrough in their work to develop semi-autonomous colonoscopy, using a robot to guide a medical device into the body. The milestone brings closer the prospect of an intelligent robotic system being able to guide instruments to precise locations in the body to take biopsies or allow internal tissues to be examined. A doctor or nurse would still be on hand to make clinical decisions but the demanding task of manipulating the device is offloaded to a robotic system.

COVID-related delays to CRC screening sees 11.9% rise in mortality

Delays in colorectal cancer (CRC) screening caused by COVID-19 has resulted in significantly increased death rates for the cancer, according to research presented at UEG Week Virtual 2020. Researchers at the University of Bologna produced a model to forecast the impact of time delays in CRC screening on CRC mortality caused by COVID-19. The results found that moderate (7-12 months) and large (>12 months) delays in screening caused a 3% and 7% increase in advanced stage CRC respectively.