Bowel cancer study shows impact of mutations on protein networks

For the first time, researchers from the Wellcome Trust Sanger Institute have completed a detailed study of many of the proteins in bowel cancer cells. They investigated the role proteins play in predicting how common mutations affect proteins in the cancer cells and also whether such proteins are important in predicting the cancer's response to treatment.

Study finds bowel cancer diagnosis delayed by other illness

The researchers from the University of Exeter who analysed clinical data from over 4,500 patients across the UK who were later diagnosed with bowel cancer have reported that if a patient has a single serious illness or mental health issue unrelated to cancer (such as depression or heart disease) their bowel cancer is diagnosed on average 10 days later than usual, a 13% increase from the usual time taken for a diagnosis.

Follow-up colonoscopies linked to lower incidence of bowel cancer

Most patients who have had treatment to remove pre-cancerous polyps or adenomas in their bowel, drastically reducing the risk of developing bowel cancer, can benefit substantially from a follow-up or 'surveillance' colonoscopy, according to a study published in the journal Lancet Oncology. However, a proportion of this group of patients are at ‘low risk’ compared with the general population and are unlikely to benefit significantly from colonoscopy surveillance.