Algorithm will improve bowel-cancer patient care

An algorithm which can predict how long a patient might spend in hospital if they're diagnosed with bowel cancer could save the NHS millions of pounds and help patients feel better prepared, according to researchers from the University of Portsmouth and the Portsmouth Hospitals University NHS Trust. The intelligent model will allow healthcare providers to design the best patient care and prioritize resources.

Accelerated biological aging may increase bowel cancer risk

Researchers have shown how accelerated biological aging measured by an epigenetic clock may increase the risk of bowel cancer, according to a report, ‘Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study’, published in eLife. The study provides evidence that biological age might play a causal role in the increased risk of certain diseases, and paves the way for interventions that could slow down this process.

C. albicans strains may damage the gut of patients with IBD

Individual Candida albicans yeast strains in the human gut are as different from each other as the humans that carry them, and some C. albicans strains may damage the gut of patients with inflammatory bowel disease (IBD), according to a study from researchers at Weill Cornell Medicine. The findings reported in the paper, ‘Immune regulation by fungal strain diversity in inflammatory bowel disease’, published in Nature, suggest a possible way to tailor treatments to individual patients in the future.

Computational biology method to better understand IBD

Scientists at the Quadram Institute, the Earlham Institute and University of East Anglia have developed a new computational biology method to better understand Inflammatory Bowel Disease (IBD) for targeted clinical treatments. By analysing specific differences in gut cell types, the method deciphers cellular crosstalk to identify how beneficial bacteria communicate with our immune system to treat IBD and reduce gut inflammation.

Green synthesis of drug candidate for inflammatory bowel disease

A research team led by Associate Professor Hiroki Kakuta from Okayama University, Japan, have developed a new large-scale synthesis method for widespread and stable supply of 4-(ethyl(3-isobutoxy-4-isopropylphenyl)amino)benzoic acid or NEt-3IB, a promising drug candidate for IBD. The research team further consisted of Yuta Takemura, Ken-ichi Morishita, Shota Kikuzawa, and Masaki Watanabe, all from Okayama University.

Are taller adults at increased risk of CRC?

A new meta-analysis by Johns Hopkins Medicine researchers has added to evidence that taller adults may be more likely than shorter ones to develop colorectal cancer or colon polyps that can later become malignant. While the association between taller height and colorectal cancer has been previously investigated, the Johns Hopkins Medicine researchers say those studies offered conflicting results, carried inconsistent measures of height and failed to include the risk of adenomas, which are precancerous colon polyps.