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Quarter of Australians with inflammatory bowel disease have used cannabis

Tue, 05/05/2020 - 16:51
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Research conducted by the Lambert Initiative for Cannabinoid Therapeutics at the University of Sydney reveals a quarter of Australians with inflammatory bowel disease (IBD) have used cannabis, predominantly from illicit sources, to manage their condition. They reported improvements in symptoms and reduced use of prescription medication.

The first Australian nationwide survey - and largest ever survey on medicinal cannabis use in IBD patients - has revealed that 25.3 percent of the 838 respondents were using or had previously used medicinal cannabis to manage their symptoms.

"The survey was inspired by the experiences of the Taylor family from the Blue Mountains: father Steven Taylor was arrested for growing cannabis to alleviate the suffering of his daughters Morgan and Taylor who suffered from severe IBD and found great relief from non-intoxicating cannabis leaf juice preparations,” explained Principal investigator and academic director of the Lambert Initiative, Professor Iain McGregor.

In Australia, IBD is becoming more prevalent, more complex and more severe, according to a PricewaterhouseCoopers report. It affects approximately one in 250 people aged five to 40. Almost 75,000 Australians have Crohn's disease or ulcerative colitis, with this number projected to increase to 100,000 by 2022.

IBD, which includes the conditions Crohn's disease and ulcerative colitis, is caused by inflammation of the gastrointestinal tract and can be debilitating. It causes symptoms including weight loss, diarrhoea and bleeding, along with chronic pain, anxiety and stress that significantly impact a patient's day to day quality of life.

The condition can be difficult to manage with conventional treatment options, which is why some patients are turning to cannabis for symptom relief.

Results from the anonymous online survey, ‘Medicinal Cannabis for Inflammatory Bowel Disease: A Survey of Perspectives, Experiences, and Current Use in Australian Patients’, published in the journal Crohn's & Colitis, examined IBD severity, medication adherence, quality of life, as well as medicinal cannabis use and its perceived impact on these measures. The survey expanded on previous surveys by accessing a larger patient population. It also allowed separation of and insights into different IBD subgroups - Crohn's disease, ulcerative colitis or ‘IBD unclassified’; and different cannabis use populations - non-user, previous user and current self-prescribed medicinal cannabis users.

The survey revealed:

  • Cannabis was predominantly obtained from illicit sources with only three respondents (1.4 percent) using legal pathways provided by the Australian government.
  • More than 90 percent of patients reported that medicinal cannabis use improved their symptom management - with greatest benefits reported for abdominal pain, stress, sleep, cramping and anxiety symptoms.
  • There were, however, fewer benefits to symptoms associated with disease pathology, such as rectal bleeding, obstructive symptoms and stool frequency/consistency/urgency.
  • Patients with ulcerative colitis who use medicinal cannabis scored higher on measures of ‘quality of life’ than non-users.

Medicinal cannabis users reported less adherence to prescribed medications and were less likely to be engaged in specialist care for their IBD, which suggests low levels of clinical engagement in many of the cannabis-using patients.

Medicinal cannabis use was associated with some minor side-effects, mostly drowsiness/sedation and memory impairment.

About half of the respondents who were actively using medicinal cannabis at the time of completing the survey also consumed cannabis recreationally, although less frequently than for medicinal purposes.

Both cannabis-using and non-using patients expressed high levels of support for the use of medicinal cannabis in IBD and interest in participating in future clinical trials of medicinal cannabis products.

"This survey is informative to future research in this field and to continuing the discussion around medicinal cannabis for IBD management - particularly so that clinicians may better understand what their patients' may already be doing to self-manage their symptoms,” added lead author, Dr Melissa Benson from the Lambert Initiative.

To access this paper, please click here