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One in eight patients with cancer harbour inherited genetic mutations

Tue, 11/03/2020 - 08:56
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Researchers at Mayo Clinic's Center for Individualized Medicine conducted genetic testing in more than 3,000 patients who were diagnosed with cancer and discovered that one in eight patients with cancer had an inherited cancer-related gene mutation. This mutation would not have been detected in half of these patients using a standard guideline-based approach. The findings, ‘Comparison of Universal Genetic Testing vs Guideline-Directed Targeted Testing for Patients With Hereditary Cancer Syndrome’, published in JAMA Oncology, confirmed that nearly 10%-25% are inherited mutations that set off a cycle of events that can lead to cancer.

"We found that 13.5% of patients had an inherited mutation in a gene associated with the development of their cancer," explained Dr Niloy Jewel Samadder, a Mayo Clinic gastroenterologist and hepatologist, who is the study's author. "Everyone has some risk of developing cancer, and in most cases the disease develops by chance. However, some people are genetically predisposed to developing certain types of cancer, such as breast or colon cancers."

He added that uncovering these hidden inherited genetic mutations could lead to opportunities for cancer management in families and targeted cancer therapies that can save lives.

In the two-year Interrogating Cancer Etiology Using Proactive Genetic Testing (INTERCEPT) study, Mayo Clinic provided free genetic testing and counselling to 3,084 Mayo Clinic patients as part of their standard cancer care. The project, representing the largest known multi-centre study of universal testing of patients with cancer, included a broad mix of cancer stages and types, including breast, colorectal, lung, ovarian, pancreatic, bladder, prostate and endometrial cancers.

The researchers were surprised to find that the standard guidelines physicians relied on to determine which patients with cancer should undergo genetic testing were only able to identify 48% of the patients with an inherited genetic mutation.

"More than half of the patients who developed cancer due to inherited mutations were being missed, and that has major implications for family members," said Samadder. "This targeted treatment would have been lost if the patients had not received genetic testing.”

During the study, when the researchers examined the effects of a genetic mutation discovery, they found that one-third of the patients with the highest-risk cancer genes had a change in their medical management, including the type of surgery or chemotherapy they received.

"Genetic testing is underutilided in cancer care, both for patients and for their families, often due to outdated guidelines that restrict testing to a narrow group of high-risk patients," said Dr Robert Nussbaum, chief medical officer of Invitae Corporation and a contributing author on the study. "All cancer patients should have access to complete genetic information that can guide their care and inform their families' health."

Equally important to the discovery of a patient's inherited cancer mutation is the potential for patients to share the heritable-cause of their disease with their relatives, allowing family members to pursue care for earlier disease detection and cancer management.

"We can help prevent cancer in their loved ones because it is genetic and they share these cancer-causing genetic changes with their children, siblings and others in their families," he said. "We can target prevention strategies for those high-risk individuals and hopefully prevent cancer altogether in future generations of their family."

All blood-related family members of patients found to have a genetic mutation were offered free genetic testing. Overall, one in five of these family members underwent testing. The next steps will be to incorporate the study findings into the care of all patients with cancer at Mayo Clinic.

"Steps are being taken to ensure all patients are offered genomic sequencing to better understand the genes that led to the development of their cancer, and how to precisely target treatment and improve survival," Samadder concluded.

To access this paper, please click here