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IBS is endoscopically identifiable from mucosal biofilms

Mon, 06/21/2021 - 11:06
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Researchers from the Department of Medicine III of the Medical University of Vienna and the University of Vienna have shown that in most cases, Irritable bowel syndrome (IBS) is associated with bacterial biofilms in the gut that are visible under endoscopic examination.

"For the first time, we have managed to identify a cause of irritable bowel syndrome and, at the same time, show how this disease can be more accurately diagnosed, classified and assessed," explained Dr Christoph Gasche, head of the Laboratory for Molecular Gastroenterology at Medical University of Vienna and leader of the study, ‘Mucosal biofilms are an endoscopic feature of irritable bowel syndrome and ulcerative colitis’, published in Gastroenterology.

According to the study, people who have taken a lot of medication over the course of their lives, so that the balance of their gut flora has been disrupted, are more likely to be affected by bacterial biofilms. Another interesting subgroup is patients who have previously had organ transplants.

"Certain drugs, such as proton pump inhibitors, can upset the balance of the bacterial ecosystem. The bacteria then go into survival mode,” he added. “To give themselves a better chance of surviving this stress, they band together for safety and form biofilms, a sort of protective space that makes them resistant to antibiotics and other environmental toxins."

In total, more than 1,000 colonoscopies were performed in a multi-centre study, and it was found that two thirds of those who had IBS symptoms also had biofilms in their small or large intestine. However, these mucosal biofilms are also found in one third of patients with ulcerative colitis.

This bacterial matrix, which can be reticular or even planar, adheres like a thin layer on the mucosal lining of the gut - not unlike dental plaque in caries - thereby impairing its functions and, hence, that of the gut.

"Up until now, it has always been assumed in investigations that this sticky film is made up of residues of impurities in the gut, which were difficult to eliminate. However, we have now been able to show that this is where the bacterial matrix adheres."

 A revolutionary discovery for the lead authors of the study, Maximilian Baumgartner und Michaela Lang, on a par "with the discovery of the rod-shaped bacterium Helicobacter pylori, which permanently changes the gastric environment."

In many cases it is possible to wash away these biofilms in the large intestine using an endoscopic "spray gun." Future studies will show whether this alleviates the IBS symptoms. Also, this technique cannot (as yet) be used to remove biofilms from the small intestine, where they also frequently occur.

In a new project funded by Vienna Science and Technology Fund, the MedUni Vienna experts are therefore already investigating how the new findings about these biofilms can be used in future to generally remove them or even to prevent them from forming in the first place. But one conclusion can already be drawn from the study results: "Biofilms reflect an imbalance in the gut flora, could well explain the symptoms of IBS patients and, hence, give rise to new therapeutic approaches," the researchers added.

To access the paper (pre-proof), please click here