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Gut bacteria might be an indicator of CRC risk

Sat, 09/18/2021 - 09:10
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The increased presence of certain bacteria in a gut biome indicates a greater likelihood that colorectal cancer (CRC) polyps will become cancerous. The findings were published in the paper, 'Genomic and functional characterization of a mucosal symbiont involved in early-stage colorectal cancer', published in Cell Host & Microbe

In his research, Dr William DePaolo, associate professor at the University of Washington School of Medicine, tracked 40 patients who had undergone routine colonoscopies and had biopsies taken near the polyps to identify bacteria present at relatively higher levels compared with those of patients who were polyp-free. All the patients were between the ages 50 and 75, and 60% were women.

DePaolo's research team found that a common bacteria, non-enterotoxigenic Bacteroides fragilis, was elevated in the mucosal biopsies of patients with polyps. The research also found distinct microbial signatures distinguishing patients with polyps from those without polyps, and established a correlation between the amount of B. fragilis in the samples and the inflammation of small polyps.

Upon closer examination, DePaolo found that the B. fragilis from patients with polyps differed in its ability to induce inflammation compared to the B. fragilis from polyp-free individuals.

"The whole idea is that most people look at advanced colorectal cancer and think of the microbiome, but it's hard to determine if the microbiome has changed and when it changed," explained DePaolo. "So, we took an earlier look at the disease and asked when might the microbiome may be pushing a polyp toward cancer."

In addition, when people think of the microbiome and its role in disease, they often think of compositional changes where a potentially dangerous bacteria takes over.

"What our data suggests is that, in order to survive within an environment where metabolic and inflammatory changes are occurring, a normally healthy gut and related bacteria may adapt in such a way that causes it to contribute to the inflammation rather than suppress it," DePaolo added.

Only 5% of the polyps in the colon actually turn out to be cancerous, he explained. He said polyps seem to develop in the same areas of the colon repeatedly and he theorised that in fact new screenings for colon cancer could look for key bacteria inhabiting the gut and the amounts of this particular strain of B. fragilis, before pre-cancerous polyps even develop.

The next step, he said, is to expand the study to 200 patients to determine whether a faecal sample might be used as a surrogate for the mucosal biopsy.