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Stress associated with Crohn's disease flare-ups

Fri, 11/19/2021 - 06:34
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A possible link between psychological stress and Crohn's disease flare-ups has been identified by a McMaster University-led study. Researchers using mouse models found that stress hormones suppressed the innate immune system that normally protects the gut from invasive Enterobacteriaceae, a group of bacteria including E. coli which has been linked to Crohn's disease. The findings were featured in the paper, ‘Psychological stress impairs IL22-driven protective mucosal immunity against colonizing pathobionts’, published in Nature Communications.

Key to innate immunity is the protective barrier of epithelial cells in the gut, which rely on molecular signals from immune cells to keep out harmful microbes, repair the cell wall and secrete mucus. Without properly functioning immune cells, the epithelial cellular wall can break down, allowing microbes associated with Crohn's disease to invade the gut and trigger symptom flare-ups.

"The main takeaway is that psychological stress impedes the body's ability to fight off gut bacteria that may be implicated in Crohn's disease,” said senior author, Dr Brian Coombes, professor and chair of biochemistry and biomedical sciences at McMaster. “Innate immunity is designed to protect us from microbes that do not belong in the gut, like harmful bacteria. When our innate immune system functions properly, it prevents harmful bacteria from colonizing us, but when it breaks down, it leaves an opening for pathogens to colonise locations they normally cannot and cause illness."

Coombes said that removing stress hormones in the mouse models restored proper function to immune cells and epithelial cells, blocking the invasion of harmful microbes.

While this discovery could lead to new treatments for Crohn's disease, Coombes emphasizes these findings are still at the pre-clinical stage and more work needs to be done.

"The more we know about what triggers Crohn's disease, the closer we come to new treatments and potentially even disease prevention," said Coombes.

While the root cause of Crohn's disease is still not fully understood, Coombes said patients with the disease often have an altered gut microbiome dominated by Enterobacteriaceae like E. coli.

The Coombes lab is part of the Michael G DeGroote Institute for Infectious Disease Research and the Farncombe Family Digestive Health Research Institute based at McMaster University. External funding for the study was provided by the Canadian Institutes of Health Research and Crohn's and Colitis Canada.